Product Description
We are the most professional real "MANUFACTURER" and "SUPPLIER" of CHOLIC ACID series materials on MIC, welcome the enquiry from both Foreign and Domestic customers.
We can provide:
(1) Cholic Acid (Free Grade 50%) CAS #:81-25-94
(2) Cholic Acid (Food Grade 90%) CAS #:81-25-94
(3) Cholic Acid (Pharmaceutical Grade 95%;98%) CAS #:81-25-94
(4) Chenodeoxycholic Acid(intermediate of Ursodeoxycholic Acid) CAS #:474-25-9
(5) 3alpha-Hydroxy-7-oxo-5beta-cholic acid(7K-LCA) CAS #:4651-67-6
(6) Ursodeoxycholic Acid(EP9/USP/IP GRADE WITH GMP) CAS #:128-13-2
(7)Tauroursodeoxycholic acid EP9 CAS #:14605-22-2
(8)Obeticholic Acid (OBCA) 98%/99% CAS #:459789-99-2
(9)Obeticholic Acid Intermediate-1(OB N-1) CAS #:915038-26-5
(10)Obeticholic Acid Intermediate-2(OB N-2) CAS #:1516887-33-4
(11)Obeticholic Acid Intermediate-3(OB M-2) CAS#:1352328-66-5
Description:
Product Name:Cholic Acid
CAS:81-25-94
Molecular Formula: C24H4005
Molecular Mass:408.58
[Appearance]: white crystal powder, no foreign substance, no obvious odor
[Melting Point]: 197~202.0ºC
[Loss on Dry]: ≤1.0%
[Residue on Ignition]: ≤0.1%
[Heavy Metal ]: ≤10ppm
[Assay Determination]: 98.0%~101.0% (dries basis)
[Related Substance]:the single impurity≤0.1%, total impurities≤2.0%
[Package and Storage Condition]: 25kg/drum, store and seal away from light
What is cholic acid?
Cholic acid is a bile acid. Bile acids are produced naturally in the body to aid in digestion of fats and certain nutrients.
People with bile acid disorders are unable to produce cholic acid normally. This can make it harder for the body to absorb nutrients important for health, growth, and body functioning. Abnormal bile acids can also build up in the body and become toxic to the liver.
Cholic acid is used in people with bile acid disorders. This medicine works by normalizing bile acid production in the body.
Cholic acid may also be used for purposes not listed in this medication guide.
Bile acid is an important component of bile and plays an important role in fat metabolism. Bile acidsare mainly found in the enterohepatic circulatory system and play a protective role through recycling. Only a small portion of bile acids enters the peripheral circulation.
The driving force for promoting bile acid enterohepatic circulation is the liver cell transport system --- absorb bile acid and secrete it into bile, cholecystokinin-induced gallbladder contraction, small bowel advancing peristalsis, active transport of ileum mucosa, and Inflow.
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol. These two major bile acids are roughly equal in concentration in humans.Derivatives are made from cholyl-CoA, which exchanges its CoA with either glycine, or taurine, yielding glycocholic and taurocholic acid, respectively.
Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and
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